Non-Coeliac Gluten Sensitives: Leaky Gut and Immune Response Confirmed

grain iconAn interesting new study just out looks at why people without the usual coeliac markers (like gliadin and transglutaminase antibodies) do in fact react to wheat and grains.

(By the way, I’m not even going to go into the fact that they are only looking for limited markers so miss most of them anyway, unlike the improved Cyrex 3 option; still not 100%, but FAR better.)

I know this doesn’t sound like news to us as we’ve been talking about the fact that non-coeliac gluten sensitivity involves a weakening of the gut barrier strength and allows systemic immune response for ages (see the Barrier Plan I wrote in 2011, for example, now the Gluten Plan!).

That said: it is always good to have a study confirm it for us – it makes it more likely to be accepted in mainstream medicine, and helps show us we are not going mad – even if docs couldn’t ‘see’ it before and told us we were imagining it. (Don’t set me off..).

Anyway, you can read the new study below. Effectively – markers for leaky gut found and systemic immune response leading to a reason why people consuming wheat and similar grains (not sure which they tested specifically) have ‘reactions’ even though they are not coeliac.

Biological explanation for wheat sensitivity found

Weakened intestinal barrier, systemic immune activation may explain symptoms in people without celiac disease

It’s all very well finding the markers and confirming the leaky gut and immune activity, but exactly what do you do about it? The Gluten Plan has my full protocol in it for you, of course. Also, see here for my leaky gut factsheet.

In fact, just this morning, I was reading another study done locally (to me) in Plymouth where they have been investigating the cause and treatment of leaky gut which is so prevalent in athletes apparently (new one on me!).

They determined that heavy exercise and increased temperature (from the exercise raising body temperature and actual heat the athletes train in) causes the barrier to become more permeable. And they found that zinc carnosine combined with colostrum is an excellent way to prevent and treat it.

Yes, of course zinc carnosine is one of the leaky gut protocol choices in the Gluten Plan, I thank you. However, I wouldn’t recommend a dairy based colostrum product for a TGF leaky gut since we know it is a very common gluten cross-reactive food. Check the plan for different choices to suit different issues.

Anyway, good research proving what we already know = progress.


5 Replies to “Non-Coeliac Gluten Sensitives: Leaky Gut and Immune Response Confirmed”

  1. Micki, thanks for sharing that article. I was very disappointed in their research which seems narrow and tunnel visioned. The researchers are avoiding looking at allied fields which could help explain the condition and its horrible effects on lives. I’ve had wheat/maize intolerance since 1993 and believe me, avoiding wheat had no effect whatsoever on my early symptons. As you’re probably aware from previous correspondence I’m severely maize intolerant as well, enough that even a small amount can give me atrial fibrillation as well as the other symptoms. When are these researchers going to see beyond wheat? There are far wider connections to the condition. Ooh, I wish I could meet them! I’ve give them a frank response!

    1. Hee hee, that made me smile; I rant at them too but some progress is better than none at all, Anna! As per, the headline says wheat but they did actually test other grains but I couldn’t see what they were; I am betting it was gliadin grains like rye and barley rather than corn – which we KNOW of course does the same thing; they’ve just not ‘tested’ it yet. Many of us have corn as the main reactive grain; they’ll get there!

  2. Self diagnosed celiac @ 30yo 30 years ago with remarkable recovery, but my health continued to decline till I went Paleo 3 years ago.
    Stress induced health failure saw me looking at diabetes & while not doubting celiac disease I wondered how much of my perceived allergy reaction was carbohydrate intolerance.
    After a confirmed Magnesium [& zinc] deficiency & crisis I have become aware of the importance of Mg, the ‘anti-stress mineral. So important for all the enzyme reactions including fructose metabolism in the liver & ATP conversion at the mitochondrial level for chronic fatigue.
    Of course my condition is many layered since my diuretic childhood, high sugar diet & low HCL production. Assimilating Mg is difficult & takes a long time.
    Diabetes needs turning on it’s head like the food pyramid should be.

    1. Absolutely agree, Andrew. In fact, I am deciding that once my Healing Plan has been written, we are going to focus on Diabetes turnaround and prevention next year; I am so sick of seeing sch a preventable issue be so prevalent. Rant rant, ha! And yes, agree too re magnesium – we have talked about it a lot on this blog. Crucial.

  3. Re magnesium, Andrew, I’ve found I need to take about 4 times the usual daily dose to keep on an even keel – more if I’m very active. And I don’t test high in mag, either. I do have a doctor specialising in orthomolecular medicine checking me annually – I just don’t leave it all to the doctors. I used to get checked more often but my condition has calmed down now that I know what to be careful of, so the doctor and I agree that it’s just maintenance now. And re diabetes, I keep my eye on ?? is it Newcastle or Leeds University that’s found you can get rid of Type 2 diabetes by three months of calorie restriction – or lapband surgery. Both work by greatly reducing food intake and the diabetes goes away. I bear that in mind, but so far haven’t needed it.

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