Actually, I think that estimation is too low and it doesn’t take account of all those with non coeliac gluten sensitivity. However, this study does show the importance of checking genes and not just relying on blood and biopsy tests.
Celiac disease (CD) is a multifactorial disorder with an estimated prevalence in Europe and USA of 1:100 and a female:male ratio of approximately 2:1. The disorder has a multifactorial etiology in which the triggering environmental factor, the gluten, and the main genetic factors, Human Leukocyte Antigen (HLA)-DQA1 and HLA-DQB1 loci, are well known. About 90-95% of CD patients carry DQ2.5 heterodimers, encoded by DQA1*05 and DQB1*02 alleles both in cis or in trans configuration, and DQ8 molecules, encoded by DQB1*03:02 generally in combination with DQA1*03 variant. Less frequently, CD occurs in individuals positive for the DQ2.x heterodimers (DQA1=*05 and DQB1*02) and very rarely in patients negative for these DQ predisposing markers. HLA molecular typing for Celiac disease is, therefore, a genetic test with a negative predictive value.
I regularly find these genes but I also find other DQ ones related to NCGS. Just because the DQ2 and DQ8 aren’t present, does not mean you can’t have some form of gluten sensitivity; it’s just that those particular ones are linked to coeliac disease specifically.
We haven’t linked the other genes yet in mainstream medicine although some experts believe that DQ1 and DQ3 are very much related to neurological, hyper-sensitivity and skin diseases linked to gluten – the non-coeliac gluten sensitivity. And that’s why my advice is always to look at all the DQ genes and not just the DQ2 and 8 looked for in mainstream medicine for ruling coeliac disease in or out.
Personally, I have a DQ8 (the DQB1*03:02 mentioned above) and a DQ1 so assume I have the potential for coeliac disease (which my malabsorption problems are no doubt related to) and have neurological (migraine), skin (eczema, skin splitting, recurrent infections) and hyper-sensitivity (multiple food intolerance) related to the DQ1.
What have you got? Here’s the full gene test and more on gluten tests generally.
Source: FoodsMatter.com gluten forum
Howdy Glutenaughts,
Compare this 1:100 ratio with the stats for Autism. Many say that the figures for Autism are downplayed as well and some set the general scope of neurological damage at 1:9. What is interesting in this article is that the ratio of female to male is reverse that of Autism. Since vaccine damage is my main focus, I would like to suggest that when a genetic test is run that the genes that may show up indicating specific tendencies may never have been your genome in the first place, but were shot into you and incorporated into your cells. Viruses, DNA and RNA debris, plasmids, subunits, etc. that are found in vaccines can either incorporate into the nucleus and/or derange the genes that are already there. This is why I am constantly experimenting with homeopathic vaccine nosodes, and miasm remedies; along with herbs that have the ability to alter DNA and/or epigenetics. The bottom line is that this is not some defect in our parents passed on to us (unless you consider mass vaccinations of previous decades the source of genetic derangement); but something that was put inside us. The 1:100 ratio alone should have medical epidemiologist investigations as front page news. About the only place that you will see proper coverage is on Miki’s website. Medical epidemiology is the study of doctor-caused illness. The 1:100 ratio was a billion times lower to warrant a bird flu and swine flu scares as a contagious epidemics, but except for this article, this news isn’t even a blip on the mainstream radar.
Well said, Patrick, thank you. Fascinating idea about the gene mutations being introduced, I hadn’t considered that. Which herbs alter DNA then, am intrigued with that?!
Hi Miki,
Give me a little bit of time to root through the link bin for a list of plants. Some are exotic East Indian ones that I will not investigate until I have more data on their chemistry. The simplest was Peppermint. I grow it. It is always much better fresh, but it is more potent fresh. So here’s the rub. If you have any bacterial overgrowth at the hiatus of the esophagus and stomach this is the typical cause of hiatal hernia/reflux. If the bacteria is still there, and/or the sphincter is weakened then peppermint will irritate it and you can get spasms. The exact same set of circumstances apply to the ileo-cecal valve. So, although peppermint is said to have antibacterial properties and (according to the link I need to send) it has DNA modification properties it doesn’t come without risks to those of us who have pre-exisiting gut problems. Another one a listmember dug up was Indian Long Pepper. It supposedly modifies the cell’s ability to absorb nutrients. Again, there is this dichotomy that according to D’ Adamo’s Blood Type Diet none of the blood types should eat any of the white or black peppers. So, I am hesitant to say too much about certain herbs until they are proven safe on myself because there is not sense in letting people experience the grief for themselves for the sake of a supposed benefit that comes with risks.
Very wise, Patrick. We will wait and see how you get on then!