Low CoQ10 Linked To Allergy

A post from Nutri today details a study that suggests children’s allergies may be partly down a deficiency of CoQ10. It’s a small study but this is a new one on me and it warrants further research I’m sure. It also makes me  wonder, if there is a link, what about all those people who develop allergies and intolerances later in life – could it be linked to statins given for high cholesterol which we know depletes CoQ10 levels? Interesting thought.
Here’s the post:
Coenzyme Q10 (CoQ10) deficiency may develop and worsen with the progression of food allergy in children. Furthermore CoQ10 deficiency may result in symptoms related to mitochondrial dysfunction and actually exacerbate allergic disease.

To investigate the presence of CoQ10 deficiency and mitochondrial abnormalities in children with food intolerance and allergies, 23 children (ages 2-16years) underwent muscle biopsies and were tested for CoQ10 levels, pathology, and mitochondrial respiratory chain activities.
It was found that compared to controls, children with food intolerance and allergies had significantly decreased muscle CoQ10. CoQ10 levels were also significantly correlated with duration of illness.
Adding insult to injury
Based on clinical experience, the study investigators suggest that mitochondrial dysfunction in children with food allergies may result in neuromuscular and seizure abnormalities and headache in certain children. In addition, experimental evidence suggests that mitochondrial dysfunction may exacerbate allergic airway inflammation.

“It seems plausible that mitochondrial dysfunction in muscle and tissues of the gastrointestinal tract of patients with food intolerance and allergies may also enhance allergic inflammation” wrote the authors.
Reviewed by Benjamin Brown N.D
Miles MV, et al. Acquired coenzyme Q10 deficiency in children with recurrent food intolerance and allergies. Mitochondrion. 2010 Sep 15. [Epub ahead of print]

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