New Autoimmune Tests Page

There is such a lot of myth and confusion surrounding autoimmunity. Most people think there’s nothing they can do about it – it’s just bad luck. That is definitely not the case, at least in some people. The biggest thing to remember is that autoimmune diseases take years to develop. The point of testing for them is to catch them before they develop to a point of no return. Here’s how to test for autoimmunity, properly.

You can see the new Autoimmune Tests page in full here, but I copy some of it below for you too.

Unsure if you need an Autoimmune Test?

Check the Autoimmunity Factsheet here for more info generally, but if you have a condition that isn’t responding to normal interventions, that waxes and wains, have one or more existing autoimmune conditions or family history of them, then it can be very wise to check.

Autoimmune disorders come on very gradually; it’s not an overnight thing at all. The real point about autoimmune testing is prevention: to catch any signs early enough to reverse any damage or at least prevent it getting any worse or you developing other types. Autoimmunity normally comes in multiples, I’m afraid, so if you have eg. autoimmune thyroid issues or coeliac disease, sadly you are at risk for more.

Testing Summary

First, ask your GP to do a quick autoimmune marker test such as ANA or ANCA, or do the Autoimmune Screening test (RG), which looks for all the main ones. Do Cyrex 5 Multiple Autoimmune Reactivity Screen for a comprehensive check, or any of the specific tissue/organ tests discussed. Then, if positive, start investigating triggers.

Initial Autoimmune Screening

If someone suspects autoimmunity might be a factor in a condition, they will usually look at the main systemic autoimmunity markers. Those are usually ANA (anti-nuclear antibodies) and ANCA (Anti-Neutrophil Cytoplasmic antibodies – easy for you to say!) and RF (rheumatoid factor). All of these are found in the Autoimmune Screening test (RG).

The idea is to find evidence that autoimmunity might be going on and then do deeper screening to identify exactly what. These also act as a good general progress marker for treatment – levels should be reducing over time if your programme is working.

More than one autoimmune antibody is looked for generally because they can appear in perfectly healthy people – especially as we age or have inflammation. The trick is to see the trend.

ANA is used mainly to help diagnose systemic lupus erythematosus (SLE), but can also be positive in cases of scleroderma, Sjögren’s syndrome, Raynaud’s disease, juvenile chronic arthritis, rheumatoid arthritis, antiphospholipid antibody syndrome, autoimmune hepatitis, polymyositis and many other autoimmune and non-autoimmune diseases.

ANCA is used when a person is suspected of having systemic autoimmune vasculitis. Early in the disease, symptoms may be vague or nonspecific, such as fever, fatigue, weight loss, muscle and/or joint aches, and night sweats. Later on, it starts to affect small blood vessels eg. in the eyes, skin.

RF may be present in people with rheumatoid arthritis but also in patients with Sjogren’s
syndrome and lupus.

The Autoimmune Screening test (RG) also includes AMA (anti-mitochondrial antibody) which screens for autoimmune liver disorders including Primary Biliary Cholangitis/ Cirrhosis (PBC).

If you find that positive and/or want a more comprehensive screen of key organs and systems, use Cyrex 5, the multiple autoimmune reactivity screen..

Multiple Autoimmunity Reactivity Screen

The Cyrex 5 test covers an awful lot of ground from parietal cells (why are you not producing stomach acid even with supplements…?), adrenals (why will they not pick up even though you’re doing all the right things?), ditto thyroid, gut autoimmunity (could this be why you can’t get your foods back in..?) to muscles, joints and connective tissues (could you have the start of an inflammatory disorder, MS or arthritis?).

Do you see how useful this is? You can see what’s covered and the conditions associated with each marker here.

Specific Autoimmune Tests

If you are being more specific, use Cyrex 6 for diabetes, Cyrex 7 or 7X for the neurological autoimmunity screen, Cyrex 8 for joint autoimmunity and Cyrex 20 for blood-brain. All of those separate tests are included in the Cyrex 5, which is what makes it so good!

Autoimmune Triggers

OK, so you’ve found some positives. That’s good and bad. Good because forewarned is forearmed and all that – you can likely prevent it progressing or may even reverse it somewhat. Bad because I’d rather it wasn’t happening, clearly.

Next, you need to think about what is triggering the autoimmunity. We used to think it was just genetic or simple bad luck, but that is no longer the case. Often, it is triggered by a food – most often gluten/grains/dairy, a pathogen/infection of some kind, or a chemical/environmental exposure or sensitivity.

Check the various sections on those out.

Gluten Tests

Allergy and Intolerance Tests

Gut Tests

Infections Tests (coming soon), but Cyrex 12 (Pathogen Screen)

Toxin & Chemical Tests

And don’t forget Vitamin & Mineral Tests either – is your body nourished enough to keep your T-reg cells under control. Vitamin D, for a start, is crucial to that.

Yep. I know what you’re thinking: blimey that’s a lot to consider!

I’m afraid it is a bit like going through a checklist with autoimmune disease because everyone’s trigger pattern is different. If it helps, so far, I have found gluten and cross-reactive gluten foods the number 1. It might not be the only factor but just by removing those triggers and making sure your Vitamin D levels are high enough can help the body regulate itself better.


1. Read the relevant summary pages (all listed on the Lab Tests page).
2. Decide which tests you need and what labs they are from. Book an Ask Micki here if you need help with this.
3. Click the BIG orange buttons below to go to the relevant labs. These are affiliate links, which will trigger a small amount of commission for me. Doing it this way means I can get on with writing and researching more stuff for us rather than doing all the test admin, but keep the business afloat at the same time. Bless you x
4. Search for the test you need. You will find collection instructions, sample reports etc and can order there. If ordering PHC or Cyrex tests via me, read the FAQ and tips on each test page.

If you get stuck, just email me:


The labs will send you your results direct. I will send you the PHC and Cyrex results with some details on what they mean and what to do next. You should get your results within 3 weeks (working days).

Interpretation & Help

Most results have very comprehensive reports nowadays to help you see what the results mean. If you need help, book an Ask Micki session to start with, check out the test videos on the You Tube channel here and the test factsheets here as I write them.

Testing Summary

First, ask your GP to do a quick autoimmune marker test such as ANA or ANCA, or do the Autoimmune Screening test (RG), which looks for all the main ones. Do Cyrex 5 Multiple Autoimmune Reactivity Screen for a comprehensive check, or any of the specific tissue/organ tests discussed. Then, if positive, start investigating triggers.

Leave a Reply