New Autoimmune Tests Page

There is such a lot of myth and confusion surrounding autoimmunity. Most people think there’s nothing they can do about it – it’s just bad luck. That is definitely not the case, at least in some people. The biggest thing to remember is that autoimmune diseases take years to develop. The point of testing for them is to catch them before they develop to a point of no return. Here’s how to test for autoimmunity, properly.

You can see the new Autoimmune Tests page in full here, but I copy some of it below for you too.

Unsure if you need an Autoimmune Test?

Check the Autoimmunity Factsheet here for more info generally, but if you have a condition that isn’t responding to normal interventions, that waxes and wains, have one or more existing autoimmune conditions or family history of them, then it can be very wise to check.

Autoimmune disorders come on very gradually; it’s not an overnight thing at all. The real point about autoimmune testing is prevention: to catch any signs early enough to reverse any damage or at least prevent it getting any worse or you developing other types. Autoimmunity normally comes in multiples, I’m afraid, so if you have eg. autoimmune thyroid issues or coeliac disease, sadly you are at risk for more.

Testing Summary

First, ask your GP to do a quick autoimmune marker test such as ANA or ANCA, or do the Autoimmune Screening test (RG), which looks for all the main ones. Do Cyrex 5 Multiple Autoimmune Reactivity Screen for a comprehensive check, or any of the specific tissue/organ tests discussed. Then, if positive, start investigating triggers.

Initial Autoimmune Screening

If someone suspects autoimmunity might be a factor in a condition, they will usually look at the main systemic autoimmunity markers. Those are usually ANA (anti-nuclear antibodies) and ANCA (Anti-Neutrophil Cytoplasmic antibodies – easy for you to say!) and RF (rheumatoid factor). All of these are found in the Autoimmune Screening test (RG).

The idea is to find evidence that autoimmunity might be going on and then do deeper screening to identify exactly what. These also act as a good general progress marker for treatment – levels should be reducing over time if your programme is working.

More than one autoimmune antibody is looked for generally because they can appear in perfectly healthy people – especially as we age or have inflammation. The trick is to see the trend.

ANA is used mainly to help diagnose systemic lupus erythematosus (SLE), but can also be positive in cases of scleroderma, Sjögren’s syndrome, Raynaud’s disease, juvenile chronic arthritis, rheumatoid arthritis, antiphospholipid antibody syndrome, autoimmune hepatitis, polymyositis and many other autoimmune and non-autoimmune diseases.

ANCA is used when a person is suspected of having systemic autoimmune vasculitis. Early in the disease, symptoms may be vague or nonspecific, such as fever, fatigue, weight loss, muscle and/or joint aches, and night sweats. Later on, it starts to affect small blood vessels eg. in the eyes, skin.

RF may be present in people with rheumatoid arthritis but also in patients with Sjogren’s
syndrome and lupus.

The Autoimmune Screening test (RG) also includes AMA (anti-mitochondrial antibody) which screens for autoimmune liver disorders including Primary Biliary Cholangitis/ Cirrhosis (PBC).

If you find that positive and/or want a more comprehensive screen of key organs and systems, use Cyrex 5, the multiple autoimmune reactivity screen..

Multiple Autoimmunity Reactivity Screen

The Cyrex 5 test covers an awful lot of ground from parietal cells (why are you not producing stomach acid even with supplements…?), adrenals (why will they not pick up even though you’re doing all the right things?), ditto thyroid, gut autoimmunity (could this be why you can’t get your foods back in..?) to muscles, joints and connective tissues (could you have the start of an inflammatory disorder, MS or arthritis?).

Do you see how useful this is? You can see what’s covered and the conditions associated with each marker here.

Specific Autoimmune Tests

If you are being more specific, use Cyrex 6 for diabetes, Cyrex 7 or 7X for the neurological autoimmunity screen, Cyrex 8 for joint autoimmunity and Cyrex 20 for blood-brain. All of those separate tests are included in the Cyrex 5, which is what makes it so good!

Autoimmune Triggers

OK, so you’ve found some positives. That’s good and bad. Good because forewarned is forearmed and all that – you can likely prevent it progressing or may even reverse it somewhat. Bad because I’d rather it wasn’t happening, clearly.

Next, you need to think about what is triggering the autoimmunity. We used to think it was just genetic or simple bad luck, but that is no longer the case. Often, it is triggered by a food – most often gluten/grains/dairy, a pathogen/infection of some kind, or a chemical/environmental exposure or sensitivity.

Check the various sections on those out.

Gluten Tests

Allergy and Intolerance Tests

Gut Tests

Infections Tests (coming soon), but Cyrex 12 (Pathogen Screen)

Toxin & Chemical Tests

And don’t forget Vitamin & Mineral Tests either – is your body nourished enough to keep your T-reg cells under control. Vitamin D, for a start, is crucial to that.

Yep. I know what you’re thinking: blimey that’s a lot to consider!

I’m afraid it is a bit like going through a checklist with autoimmune disease because everyone’s trigger pattern is different. If it helps, so far, I have found gluten and cross-reactive gluten foods the number 1. It might not be the only factor but just by removing those triggers and making sure your Vitamin D levels are high enough can help the body regulate itself better.


You can view details, sample reports, collection instructions and order all tests mentioned via Regenerus (RG) and Medichecks (MC). There are a few that I couldn’t get elsewhere via me (PHC) and Cyrex tests are also here (Cyrex).

Use the search facility at each lab to find the test I’ve mentioned. Please direct all questions on doing tests, shipping, payment, getting results, interpretation etc to the labs. For Cyrex and PHC tests, you can contact me after reading the FAQ and the test pages, tips etc if you’re still stuck. You should get your results within 3 weeks (working days) direct from the labs (or me for PHC/Cyrex). Medichecks includes phlebotomy, Regenerus has a list of phlebotomy clinics where you can get blood samples taken.

Please note: I am no longer doing test analysis or interpretation; this facility is to enable you to identify, learn about and order tests not easily available elsewhere. I get a small amount of commission when you order, which helps me keep this service and website going – thank you from all who benefit!

Testing Summary

First, ask your GP to do a quick autoimmune marker test such as ANA or ANCA, or do the Autoimmune Screening test (RG), which looks for all the main ones. Do Cyrex 5 Multiple Autoimmune Reactivity Screen for a comprehensive check, or any of the specific tissue/organ tests discussed. Then, if positive, start investigating triggers.

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