Magnesium Deficiency: A Public Health Crisis?

I nearly fell off my chair this morning as this statement is from an article in Open Heart Journal (in the BMJ stable) – so this is mainstream medicine calling for magnesium deficiency to be recognised and acted upon, calling it a primary driver of cardiovascular disease.

You can read the fascinating but very technical article in full below:

Coronary artery disease

Subclinical magnesium deficiency: a principal driver of cardiovascular disease and a public health crisis

Subclinical magnesium deficiency is a common and under-recognised problem throughout the world. Importantly, subclinical magnesium deficiency does not manifest as clinically apparent symptoms and thus is not easily recognised by the clinician.

Despite this fact, subclinical magnesium deficiency likely leads to hypertension, arrhythmias, arterial calcifications, atherosclerosis, heart failure and an increased risk for thrombosis. This suggests that subclinical magnesium deficiency is a principal, yet under-recognised, driver of cardiovascular disease.

A greater public health effort is needed to inform both the patient and clinician about the prevalence, harms and diagnosis of subclinical magnesium deficiency.

Blimey, at last! I do go from feeling immensely frustrated that nutritionists have been pointing to the evidence for this for years (I was first trained in the importance of magnesium in any circulatory disorder back in the 90s!) to feeling thankful that mainstream medicine has at last woken up to it!

Heart disease is the number one killer in the UK, far ahead of cancer, so this is important news.

How do you test for magnesium deficiency?

As they say in the article, magnesium deficiency often goes undiagnosed because they are testing serum, which doesn’t show you what the true intracellular level is. This is why I always recommend red cell magnesium levels are tested (on the shop from Biolab or in the Genova Toxic & Essential Elements test) or white blood cell intracellularly using eg Spectracell.

Because serum magnesium does not reflect intracellular magnesium, the latter making up more than 99% of total body magnesium, most cases of magnesium deficiency are undiagnosed. Furthermore, because of chronic diseases, medications, decreases in food crop magnesium contents, and the availability of refined and processed foods, the vast majority of people in modern societies are at risk for magnesium deficiency.

Certain individuals will need to supplement with magnesium in order to prevent suboptimal magnesium deficiency, especially if trying to obtain an optimal magnesium status to prevent chronic disease. Subclinical magnesium deficiency increases the risk of numerous types of cardiovascular disease, costs nations around the world an incalculable amount of healthcare costs and suffering, and should be considered a public health crisis. That an easy, cost-effective strategy exists to prevent and treat subclinical magnesium deficiency should provide an urgent call to action.

Here, here!

The article goes on to suggest magnesium loading or retention tests are the best but the magnesium usually has to be injected so has to be done in the clinical setting – ask for GP or consultant. The labs have found red blood or other intracellular tests to correlate well and those are easier to get done! I tend to use Biolab for this mostly and here is an interesting factsheet on magnesium testing for you from them.

I also look at the Morley Robbins testing parameters. He says anything below 6mg/dl or less than 2.46mmol/L is a deficiency level.

So what are the symptoms of magnesium deficiency?

These are taken from the article.

Potential clinical signs of magnesium deficiency

Less severe signs

  • Aggression.152

  • Anxiety.

  • Ataxia.

  • Chvostek sign80 (twitching of the facial muscles in response to tapping over the area of the facial nerve).

  • Confusion.

  • Cramps (spontaneous carpopedal spasm or painful cramps of the muscles in your hands and feet).

  • Disorientation.

  • Fasciculations (‘a brief, spontaneous contraction affecting a small number of muscle fibres, often causing a flicker of movement under the skin. It can be a symptom of disease of the motor neurons)’.91

  • Hyper-reflexia.

  • Irritability.

  • Muscular weakness.

  • Neuromuscular irritability.

  • Pain or hyperalgesia206 (decreases the nociceptive threshold).

  • Photosensitivity.207

  • Spasticity.

  • Tetany204 (involuntary muscle spasms).

  • Tinnitus208 (ringing in the ears).

  • Tremors.

  • Trousseau sign.

  • Vertigo.

  • Vitamin D resistance.

Severe signs

  • Arrhythmias (caused by overexcitation of the heart due to enhanced depolarisation susceptibility, especially torsades de pointes or ventricular tachycardia with a prolonged QT interval).

  • Calcifications (soft tissue).

  • Cataracts.209

  • Convulsions.

  • Coronary artery disease.

  • Depressed immune response.210

  • Depression.211

  • Hearing loss.152 212

  • Heart failure.

  • Hypertension.

  • Migraines/headaches.

  • Mitral valve prolapse.213

  • Osteoporosis.

  • Parathyroid hormone resistance and impaired parathyroid hormone release/function.214

  • Psychotic behaviour.

  • Seizures215 (overexcitation of the nervous system (nerve cells), which are more likely to fire due to a reduced electric potential difference between the outer and inner surfaces of the membrane).2

  • Sudden cardiac death.

  • Tachycardia.

A lot there, aren’t there? This is because magnesium is involved in over 300 different enzymatic pathways in the body, so lack of it will affect any or all of them. I can certainly attest to having either suffered or seen clinically quite a few of those that were helped by magnesium repletion. Mostly calcification – hard muscles and joint spurs – migraine, arrythmia, osteoporosis, anxiety, hypertension, cramps, muscle pain, tinnitus, twitching and vertigo.

What magnesium should you take?

There is a bit of debate about this as there are many different forms of magnesium. Definitely not oxide, which is very unabsorbable and causes diarrhoea. I tend to go for citrate because it has high bioavailability and much research on absorption behind it, or I use magnesium chloride spray on skin or flakes in the bath. Here is a really useful article all about magnesium and the various supplement forms from AOR, whose research I trust.

Understanding Different Types of Magnesium

As you can see, you can mix and match magnesium types to suit what you need from them. You can get magnesium supplements of whatever type from either my shop here or from ND as usual (pls give my name). I’ve also hopefully got a person coming on to the clinical team soon who is going to be my mineral specialist, especially to do with magnesium as it is just so important, so watch this space. I’ll let you know if it works out.

OK, hope that helps. I would say pretty much most people could use more magnesium. Biolab actually told me that they find about 70% of patients tested are found to be too low. That is huge – especially given the UK rates of heart disease, let alone all those other symptoms. For me: think magnesium, not calcium which is all you ever tend to hear about, isn’t it?!

Have you got any magnesium stories to share? Do share below..





3 Replies to “Magnesium Deficiency: A Public Health Crisis?”

  1. I take magnesium three times a day ie three times the daily dose. It reduces to near zero my heart flutter, it stops me having restless leg syndrome and it just makes me feel all-ver better. This doctor is late to the party, eh?

  2. Yet another nutrient which can explain my mild ataxia symptoms. 🙂 I’ll have my mineral and vitamin levels checked soon, so I’m excited to find out what’s going on!

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