New Diabetes Risk Tests

Are you at risk of type 2 diabetes or heart disease? Would you like to know where you are along the road towards it (or not, hopefully!)?

Well two new cutting-edge tests from Genova can now help you answer that question. Using several factors, you can now do a PreD (pre-diabetes) Guide test which will give you an idea what your current risk is and where that risk is coming from so you can do something to prevent diabetes developing. Fascinating and extremely useful given the current diabetes epidemic we are in the middle of.

If you feel, you may have a risk of heart disease/metabolic syndrome (the combination of diabetes and cardio-vascular/fat problems like high cholesterol, high LDL, triglycerides etc), there is an even more predictive test, MetSyn Guide which basically does the Prediabetes test alongside very specific lipid (fat) measurements to show early risk of problems.  Again, extremely useful.

Here is some blurb on how the test identifies the three main stages of diabetes, and the info on the lipid side of things:

Identifying the Stage of Progression

Adiponectin is produced and secreted by fat cells, and regulates lipid and glucosemetabolism.It influences the body’s response to insulin, and has anti-inflammatory effects on the cells that lineblood vessel walls. Patients with high levels of adiponectin have a reduced risk of heart attack anddiabetes. Falling adiponectin levels are the hallmark of the first stage of progression to diabetes.

Insulin, Glucose, and Hemoglobin A1C – Thesemarkers are traditionally used to provide clinicalinsight into blood glucose regulation. HOMA-IR (homeostasismodel assessment–insulin resistance)is a calculation based on fasting plasma glucose and fasting plasma insulin levels that wasdeveloped as a surrogatemeasurement of insulin resistance. Rising insulin levels in the presence ofdiminished adiponectin levels are the hallmark of the second stage of progression to diabetes.

Proinsulin is the prohormone precursor to insulin, and is secreted by pancreatic beta cells. Rising proinsulin levels in the presence of elevated insulin levels and diminished adiponectin levels areindicative of beta-cell dysfunction, the hallmark of the third stage of progression to diabetes.

Identifying the Dyslipidemia of Insulin Resistance

Advanced lipid biomarkers focus on particle concentration (LDL-P and small LDL-P), in addition to standard cholesterol measures (e.g. LDL-C and Triglycerides). According to the American Diabetic Association (ADA) and the American College of Cardiology (ACC), LDL particle concentration is more closely associated with obesity, diabetes, insulin resistance, andother markers of cardio-metabolic risk than LDL cholesterol or non-HDL cholesterol.Treatment regimens to lower LDL-P, which is more prevalent with insulin resistance, differ from treatment approaches for elevated LDL-C.”

I like these tests because they are preventative. Knowledge is power and with test results like this, you can pretty much avoid life-long illness before it develops too far. Not cheap, I’ll admit, but excellent value for gaining that powerful knowledge in my view. If you have a family history of type 2 diabetes, obesity (especially around the middle) or cardiovascular disease, take a close look and consider doing them.

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