As you can tell, I am catching up with stuff I haven’t been able to do with my Adrenal Plan writing hat on!
Hot on the heels of the new NeuroHormone tests, I have also changed the Vitamin B12 and Anaemia tests, which I know again that some of you have been waiting for me to do!
Why have I changed them?
Well, I have been coming across quite a few people who test fine on serum B12, but who quite clearly have B12 deficiency symptoms and who go on to improve on a B12 supplement trial.
Of course, I had to look into it. And, as Providence or someone or other would have it, TDL labs was also doing the same thing and had just introduced a new Active B12 test. Basically, like the red blood cell mineral tests, this looks for the metabolic levels of B12 rather than what is just in your blood. Here is some info on that for you (bit techy, but you get the point):
What is Active B-12?
Three carrier proteins are involved in the transport of Vitamin B12 around the body – Intrinsic Factor (IF), transcobalamin (TC) and haptocorrin (HC).
When transcobalamin and haptocorrin bind Vitamin B12 the resulting complexes are known as holotranscobalamin (HoloTC) and holohaptocorrin (HoloHC).
Holotranscobalamin represents only 10-30% of the Vitamin B12 circulating in the blood but is the ONLY form of Vitamin B12 that is taken up and used by cells of the body, hence it’s other name… ACTIVE-B12.
Only transcobalamin transports Vitamin B12 from its site of absorption in the ileum to tissues and cells. The vitamin is then internalised as the Active-B12 (vitamin B12 bound to transcobalamin) complex via a specific receptor-mediated uptake. This process delivers Vitamin B12 into the cells of the body and provides the vitamin as an essential co-enzyme for vital cellular functions such as DNA synthesis..
The remaining 70-90% of circulating Vitamin B12 is bound to haptocorrin, the function of which is unknown.
Because up to 90% of circulating Vitamin B12 is bound tohaptocorrin and is therefore biologically unavailable for most cells, the traditional Total B12 test can give a misleading representation of the patient’s Vitamin B12status. Active-B12, the part of Vitamin B12 bound to transcobalamin (TC), is the portion that delivers Vitamin B12 to the tissues of the body.
Also, Active-B12 has a shorter circulating half-life compared to holohaptocorrin so the earliest change that occurs on entering negative vitamin B12 balance is very likely to be a decrease in Active-B12 concentration
So, a no-brainer then to change to measuring active B12. You can see the new Vitamin B12 test here for more info.
I also wanted to extend the anaemia test to include the new active B12, but also red cell folate instead, again, of the usual serum type, and a few other indices too, including ESR for inflammation since high levels in the body can lead to misleading iron results. It’s all very technical, y’know; I don’t just make this stuff up 😉
Anyway, I think the new anaemia test is much improved on the last one but I can still do the previous Genova one if you need to do comparisons, so just ask. I’ve taken it off the shop site so I don’t confuse with having two anaemia tests.
OK, see the new Active B12 test here and the new Anaemia test with active B12 and red cell folate here.
Blimey, doing those hormone, neurotransmitters, adrenal, cortisol, B12 and anaemia test changes has taken me all day and I am shattered now! Hope they help you; am rather pleased with myself 🙂